Optimizing Dendritic Cell Function by Genetic Modification
نویسندگان
چکیده
منابع مشابه
Optimizing dendritic cell function by genetic modification.
The potential for effective immune therapy for cancer has been met with considerable enthusiasm because of a number of fundamental advances in our understanding of the immune responses to cancer. First, previous questions about the existence of tumor antigens have largely been answered, since tumorassociated and tumor-specific antigens clearly exist and, when they are recognized by antigen-spec...
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An alternative approach to the use of tumor-peptide-loaded dendritic cells (DC) in immunotherapy would be the use of genetically modified DC using viral vectors expressing tumor-associated antigens (TAA). However, viruses have developed several immune escape mechanisms and, thus, one has to study the interaction between viruses and DC before these viruses can be used as an alternative strategy....
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ژورنال
عنوان ژورنال: JNCI Journal of the National Cancer Institute
سال: 2000
ISSN: 0027-8874,1460-2105
DOI: 10.1093/jnci/92.15.1198